1. How to submit my research paper? What’s the process of publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
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The journal publishes full research papers.[Read More]
IJPMBS 2024 Vol.13(1): 19-29
doi: 10.18178/ijpmbs.13.1.19-29

Home-Based Mice Colony Explores the Effect of Light Therapy on the Cognitive Functions of Circadian Rhythm Disruption in Mice

Robin Dao 1 and Pingchuan Ma 2,*
1. YK Pao School, Shanghai, China
2. Washington University, St. Louis, MO, USA
Email: robinchrisdao@163.com (R.D.); mapingchuan@wustl.edu (P.M.)
*Corresponding author

Manuscript received May 25, 2023; revised July 7, 2023; accepted August 17, 2023; published February 7, 2024.

Abstract—The fast and non-invasive modulation of brain activity has shown promising therapeutic potential for treating neurological disorders. Gamma-frequency light therapy has been proven effective in treating neurodegenerative diseases. However, its broader therapeutic potential remains unclear. In this study, light therapy was used to treat cognitive dysfunction induced by circadian rhythm disruption in mouse models. First, a light therapy treatment device was built to produce flickering LED light at a 30 Hz gamma frequency. Second, a home-based mouse colony and an artificial circadian rhythm induction chamber were built to induce circadian rhythm disruption in mice during different patterns of light-dark cycles. Circadian rhythm induction was confirmed by video tracking and analysis. Mouse behavior tasks, including the Morris water maze test, forced swim test, and open field test, tested the spatial learning and memory, depression levels, and stress levels of the mice, respectively. The results showed that circadian rhythm disruption affected the spatial learning and memory of the mice but had negligible effects on depression and stress levels. Light therapy was able to improve the spatial learning and memory dysfunction in a specific group of circadian-disrupted mice. This study demonstrates the feasibility of light therapy as a treatment for circadian rhythm disruption. More efforts are needed to understand the mechanisms underlying the effects of light therapy and feasibility for human use.
Keywords—light therapy, circadian rhythm, circadian rhythm disruption, spatial learning and memory, anxiety, depression

Cite: Robin Dao and Pingchuan Ma, "Home-Based Mice Colony Explores the Effect of Light Therapy on the Cognitive Functions of Circadian Rhythm Disruption in Mice," International Journal of Pharma Medicine and Biological Sciences, Vol. 13, No. 1, pp. 19-29, 2024.

Copyright © 2024 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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