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The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
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The journal publishes full research papers.[Read More]
IJPMBS 2024 Vol.13(1): 14-18
doi: 10.18178/ijpmbs.13.1.14-18

Neural Mechanisms Underlying Brain Gamma Entrainment after Periodic Auditory Stimulation at Gamma Frequency

Haian Shao1, Haiping Shao1, and Weijia Wang2,*
1. Lexington High School, Lexington, Massachusetts, United States
2. Shanghai Jiao Tong University, Shanghai, China
Email: ericshao2004@gmail.com (H.S.); petershao22@gmail.com (H.S.); Chinavirgiathekite@gmail.com (W.W.)
*Corresponding author

Manuscript received May 25, 2023; revised July 14, 2023; accepted August 10, 2023; published January 24, 2024.

Abstract—External sensory stimuli presented at gamma frequency have been shown to mitigate cognitive symptoms in Alzheimer’s disease. However, the neural mechanisms underlying this therapeutic effect remain elusive. In this study, we investigated the effects of auditory stimulation at gamma frequency on brain oscillations and the role of theta oscillations in the process of entrainment in a group of dementia patients. Our findings indicate that external auditory stimulation at gamma frequency effectively produces gamma entrainment in the brain, and high theta power at rest predicts the level of gamma entrainment. These data suggest that external sensory stimulation modulates brain oscillations by enhancing gamma entrainment, particularly in patients with higher theta power. Our study sheds light on the potential future applications of non-invasive external sensory stimulation at gamma frequency in treating neurodegenerative diseases. However, the mechanisms underlying the generation of theta and gamma oscillations and their interactions are still not fully understood, and further research is needed to investigate these mechanisms and to develop targeted treatments that can enhance cognitive function by modulating brain oscillations. In summary, our study provides valuable insight into the potential therapeutic benefits of gamma frequency stimulation in the treatment of Alzheimer’s disease and highlights the importance of understanding neural oscillations in the brain. 
Keywords—Alzheimer’s disease, gamma frequency, auditory stimulation, brain oscillations 

Cite: Haian Shao, Haiping Shao, and Weijia Wang, "Neural Mechanisms Underlying Brain Gamma Entrainment after Periodic Auditory Stimulation at Gamma Frequency," International Journal of Pharma Medicine and Biological Sciences, Vol. 13, No. 1, pp. 14-18, 2024.

Copyright © 2024 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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