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The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
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The journal publishes full research papers.[Read More]

Application of Sensitivity Analysis for Molecular Drug Targets Searching with Regard to the NF-κB Signaling Pathway

Malgorzata Kardynska, Jaroslaw Smieja, and Krzysztof Puszynski
Institute of Automatic Control, Silesian University of Technology, Gliwice, Poland

Abstract—Sensitivity methods have been originally developed for analysis of technical systems. Recently these methods have gained increasing importance in the analysis of biological systems. Among others, they allow to rank parameters of mathematical model describing complex biological system, according to their influence on system behavior. These parameters represent biochemical processes crucial for a given biological system and their modification (e.g. by using pharmacological agents) may prove beneficial in the treatment of many diseases. In this work, we propose a novel method of sensitivity analysis based on the frequency distribution of a model transient response. The method may be used to find potential molecular targets for new drugs and takes into account the heterogeneity of cell population with respect to their responses to a drug agent.

Index Terms—sensitivity analysis, frequency distribution, signaling pathways, NF-κB, molecular drug targets

Cite: Malgorzata Kardynska, Jaroslaw Smieja, and Krzysztof Puszynski, "Application of Sensitivity Analysis for Molecular Drug Targets Searching with Regard to the NF-κB Signaling Pathway," International Journal of Pharma Medicine and Biological Sciences, Vol. 10, No. 2, pp. 82-87, April 2021. doi: 10.18178/ijpmbs.10.2.82-87

Copyright © 2021 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.

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