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Development of Amoxicillin-Loaded Modified Polycaprolactone Microparticles in Medical Application

Chalita Metheeparakornchai1, Narumol Kreua-ongarjnukool1, Saowapa Thumsing Niyomthai1, Prasit Pavasant2,3,4, and Chalida Nakalekha Limjeerajarus4
1.Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Thailand
2.Excellence Center in Regenerative Dentistry, Thailand
3.Mineralized Tissue Research Unit, Thailand
4.Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand
Abstract—Amoxicillin is realized as significant drug due to their essential inhibition of bacterial infections. However, the effective time of amoxicillin in clinical position is less than 8 hours. Therefore, this research was to prolong the drug delivery system. Chitosan was modified by PCL (PCL/CS) microparticles were fabricated by oil in water emulsion (o/w emulsion) techniques for the protection and controlled the release of amoxicillin. The ratio of PCL: chitosan at different ratios were investigated for their influences on the zeta potential, size, morphology, swelling ratio and the release rate of amoxicillin from PCL/CS microparticles. The encapsulation efficiency was 74% to 83% and the maximum cumulative released amounts of amoxicillin from the PCL/CS at ratio 1:5 was about 6.5±0.03 mg for 7 days. Furthermore, the antimicrobial of amoxicillin was demonstrated by antimicrobial activity assays, which are effective in treating Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The PCL/CS was enough for the bacterial inhibition growth of E. coli and S. aureus. The PCL/CS could be appropriate to supply a model the drug delivery system for the medical application.
Index Terms—polycaprolactone, chitosan, amoxicillin, microemulsion, antibacterial

Cite: Chalita Metheeparakornchai, Narumol Kreua-ongarjnukool, Saowapa Thumsing Niyomthai, Prasit Pavasant, and Chalida Nakalekha Limjeerajarus, "Development of Amoxicillin-Loaded Modified Polycaprolactone Microparticles in Medical Application," International Journal of Pharma Medicine and Biological Sciences, Vol. 10, No. 2, pp. 88-93, April 2021. doi: 10.18178/ijpmbs.10.2.88-93

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