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Antioxidant and Hepatoprotective Activity of Garlic Chives (Allium tuberosum) Ethanolic Extract on Doxorubicin-Induced Liver Injured Rats

Ika R. Sutejo and Erfan Efendi
Departement of Biochemistry, Faculty of Medicine University of Jember, Jember, Indonesia

Abstract—The plant phenolic compounds such as flavonoids and isoflavons have an important role in the treatment of many diseases and some of them induce a potent antioxidant and hepatoprotective effect. The objective of this study is to investigate the antioxidant and hepatoprotective activity of flavanoids compound from ethanolic extract of Allium tuberosum (EAT) against doxorubicin-induced hepatotoxicity in male Wistar rats. Preliminary phytochemical tests of EAT were done by Thin Layer Chromatography. Antioxidant and hepatoprotective activity of EAT was evaluated by treating groups of rats with 500 &1000 mg/kg body weight per oral of EAT for 14 days and at the same time (day-1 and day-8) challenging with 4.67 mg/kg body weight of Doxorubicin. On day-15 the hepatoprotective and antioxidant effects of EAT were evaluated by measuring liver function and MDA serum spectrophotometrically using standard procedures. Thin Layer Chromatography indicate the presence of the flavanoids on EAT. Results showed that intraperitoneal injection of Doxorubicin caused a significant (p<0.001) elevation in the serum levels of SGOT and SGPT. However, elevations in the measured biochemical parameters were significantly (p<0.05 and p<0.01) attenuated in rats treated with EAT, in dose related fashion. Oral administration of EAT also decreases levels serum MDA (p<0.01). It can be concluded that ethanolic extract of Allium tuberosum has a significant hepatoprotective and antioxidant activity. In addition, Allium tuberosum may be useful for adjuvant chemotherapy doxorubicin.

Index Terms—Allium tuberosum, antioxidant, doxorubicin, SGOT, SGPT

Cite: Ika R. Sutejo and Erfan Efendi, "Antioxidant and Hepatoprotective Activity of Garlic Chives (Allium tuberosum) Ethanolic Extract on Doxorubicin-Induced Liver Injured Rats," International Journal of Pharma Medicine and Biological Sciences, Vol. 6, No. 1, pp. 20-23, January 2017. doi: 10.18178/ijpmbs.6.1.20-23
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