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Release of Propranolol Hydrochloride from Matrix Capsules/Disc: Effect of Matrix Additives

Benchawan Chamsai and Wipada Samprasit
Department of Pharmaceutical Technology, College of Pharmacy, Rangsit University, Pathum Thani, 12000, Thailand

Abstract—Propranolol Hydrochloride (PPH), non-cardio selective beta blocker, has been widely used to manage the hypertension, phaeochromocytoma, angina pectoris, myocardial infarction and cardiac arrhythmias. PPH has a short half-life (3-4 hours) so it was selected as a model drug for controlled release to minimize the fluctuations of blood pressure. The aim of this research was to develop the controlled release PPH with the various additives i.e., Ethylcellulose (EC), Hydroxypropyl Methylcellulose (HPMC), Hydrogenated Vegetable Oil (HVO) and Glyceryl Monostearate (GMS). Eighty milligrams of PPH was mixed with the different types (EC, HPMC, HVO or GMS) and concentrations (30 to 60 %w/w) of the additives. The mix powders were granulated into granule using wet granulation, and then the fine granule was filled into the capsules or compressed into the tablets discs. The PPH labeled amount and release characteristics were further evaluated according to the United States Pharmacopoeia (USP31). The results show that PPH matrixes were successfully prepared by wet granulation method. For all formula, the PPH content was within the range of 90-110 %. The release of PPH from formulation containing 30% w/w of HPMC and HVO was significantly retarded. Moreover, the release kinetics of PPH disc was followed by Higuchi’s model. The PPH release was governed by diffusion mechanism. In conclusion, these HPMC and HVO matrixs can be effectively controlled the PPH release.

Index Terms—Propranolol Hydrochloride (PPH), matrix additives, controlled release

Cite:Benchawan Chamsai and Wipada Samprasit, "Release of Propranolol Hydrochloride from Matrix Capsules/Disc: Effect of Matrix Additives," International Journal of Pharma Medicine and Biological Sciences, Vol. 9, No. 2, pp. 52-55, April 2020. doi: 10.18178/ijpmbs.9.2.52-55

Copyright © 2020 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.

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