Abstract—Background: Methicillin resistant Staphylococcus aureus (MRSA) was discovered in1960 in United Kingdom since then MRSA continues to be a major burden on world¡¯s health and economy. The prevalence of MRSA with in hospital environment has increased in the recent years. According to several recent reports, the incidence of MRSA has doubled, which has increased the morbidity and mortality among the patients. Aims and objectives: This study was conducted to know the prevalence of MRSA and its antibiotic susceptibility pattern. Materials and methods: MRSA strains were isolated from pus samples over a period of one year by using standard protocols. The sensitivity pattern was found out according to Clinical laboratory standard institute. Results: A total of 4271 pus samples were processed, of these 1250 (29.26%) were S. aureus . Out of 1250 S. aureus 865(69.2%) were MRSA. These isolates were most sensitive to vancomycin 824 (95.72%) followed by linezolid 725 (83.83%) and amikacin 514 (59.4%). Forty two (4.8%) isolates were resistance to all drugs including vancomycin. Conclusion: Our study shows the prevalence of MRSA in pus samples was 20.25%. Of total isolates 4.8% were vancomycin resistant, which is more as compared to previous studies. So this is suggested to make antibiotic policy to prevent health associated infections.