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Intrinsic Blood Coagulation Studies in Patients Suffering from both Diabetes and Hypertension

ADONU Cyril C1, UGWU Okechukwu P C2, BAWA Abubakar3, OSSAI Emmanuel C2, and NWAKA Andrew C4
1 Department of Pharmaceutics, University of Nigeria,Nsukka, Enugu State, Nigeria.
2 Department of Biochemistry, University of Nigeria,Nsukka, Enugu State,Nigeria.
3 Department of Preliminary and Remedial Studies, Federal Polytechnic Mubi, Adamawa State, Nigeria.
4 Department of Biochemistry, Anambra State University, Uli, Nigeria.

Abstract—Thirty (30) citrated blood samples from patients (aged 20-60 years) suffering from both diabetes and hypertension attending diabetic clinics at University of Nigeria Teaching Hospital UNTH Ituku Ozalla in Enugu who have had the disease for at least six months were investigated. Also, investigated was a control group of thirty (30) non-diabetic and non-hypertensive individuals. Their Fasting Blood Sugar (FBS) levels and Blood Pressure (BP) were measured using standard methods. Their Body Mass Indices (BMI) was determined by measuring their weights and heights using standard methods. The results showed that the fasting blood sugar level (249.5 ± 105.66) mg/dL, BP 156+16/9 ± 6.5 mm Hg and Activated Partial Thromboplastin Time (APTT) (27.13 ± 6.4) s were statistically significant ( P <0.05). The FBS and BP were significantly higher in the diabetic hypertensive patients than in the control subjects. The APTT was significantly lower in diabetic hypertensive patients than in the control subjects ( P <0.05). The pearson correlation coefficient ( r ) showed an established negative correlation between the age of the diseases and the average APTT values ( r =0.804, t =4.8736 and P <0.05). But, there was no correlation established between the BMI and APTT values for these patients ( r =0.101, t =0.3660 and P >0.05). It could be inferred from the studies that diabetics with hypertension showed reduced APTT values which occurred in both lean and obese patients.

Index Terms—Diabetic, Hypertensive, Patients, BMI, APTT, FBS and BP

Cite: ADONU Cyril C, UGWU Okechukwu P C, BAWA Abubakar, OSSAI Emmanuel C, and NWAKA Andrew C, "Intrinsic Blood Coagulation Studies in Patients Suffering from both Diabetes and Hypertension," International Journal of Pharma Medicine and Biological Sciences, Vol. 2, No. 2, pp. 36-45, April 2013.
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