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The Study of Protective Effects of Low-Level Light and Donepezil Against β-Amyloid-Induced Cytotoxicity in SH-SY5Y Cells

Siriluk Thammasart1, Kwanchanok Viravaidya-Pasuwat2, and Anak Khantachawana2
1.Biological Engineering Program, Bangkok, Thailand
2.Department of Chemical Engineering, Department of Mechanical Engineering, and Biological Engineering Program, Bangkok, Thailand
Abstract—The main purpose of this study was to evaluate whether donepezil and Low-Level Light Therapy (LLLT) shown to play neuroprotective effects by stimulating mitochondrial activity in the amyloid-beta 1-42 (Aβ1-42) -induced neuronal toxicity model of Alzheimer’s Disease (AD). This result indicates that the Aβ1-42 accumulation in neuronal cells is related to the mitochondrial dysfunction and induced-neuronal cell death. While donepezil and Low-Level Light Therapy (LLLT; 660 nm, 5mW/cm2, 3J/ cm2) can reverse this situation. Donepezil is therapeutic acetylcholinesterase inhibitor currently being used for the treatment of AD. SH-SY5Y cells were pre-treated by donepezil at a concentration of 1 µM showed a maximum of neuronal viability compared to control cells. However, at higher concentrations, the neuronal viability was diminished. LLLT is a noninvasive therapy which showed significant increasing of neuronal viability and afforded protection against Aβ1-42-induced toxicity. In addition, the combination treatment between 1 µM of donepezil pre-treatment and LLLT in SH-SY5Y cells induced by Aβ1-42 toxicity had increased cell viability. In aggregate, these results demonstrate that LLLT has probably contributed to alternative treatment in neurodegenerative disease. 

Index Terms—Alzheimer’s disease, Beta-Amyloid, low-level light therapy, donepezil hydrochloride

Cite:Siriluk Thammasart and Kwanchanok Viravaidya-Pasuwat, and Anak Khantachawana, "The Study of Protective Effects of Low-Level Light and Donepezil Against β-Amyloid-Induced Cytotoxicity in SH-SY5Y Cells," International Journal of Pharma Medicine and Biological Sciences, Vol. 8, No. 3, pp. 100-105, July 2019. doi: 10.18178/ijpmbs.8.3.100-105

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