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Safety and Efficacy Evaluation on Combination of Lansium domesticum Fruit Extract and Hibiscus rosa-sinensis Flower Extract as Lightening Agent for Cosmetic

Kilala Tilaar1, Maily1, Fransiska Devi Junardy1, Erna Subroto1, and Diah Puspitosari2
1. Kilala Tilaar, Maily, Fransiska Devi Junardy, and Erna Subroto
2. Departement of Dermatology and Venereology, Medical Faculty, Padjadjaran University, Bandung, Indonesia
Abstract—This study was designed to investigate the potency of a combination of Lansium (Lansium domesticum) fruit extract and Hibiscus (Hibiscus rosa-sinensis) flower extract (LHE) as cosmetic active ingredient. The in vitro tyrosinase inhibition method was used to evaluate the potency of LHE in inhibit melanin production thus potential to delivered lightening benefits for skin. The result was confirmed by 4-week in vivo lightening study on human skin. Prior to this in vivo efficacy study, safety evaluation was conducted using Single Closed Patch Test (SCPT) for skin and Hen's Egg Test – Chorioallantoic Membrane (HET-CAM) to evaluate the irritation at ocular level. LHE showed tyrosinase inhibition of 49.37%, which indicates that LHE has potency to be used as lightening active ingredients in cosmetics products. After 4 weeks of application in human skin, the efficacy test showed that LHE contained lotion base significantly increased skin moisture content and reduced its melanin index. Furthermore, safety evaluation of the lotion by SCPT and HET-CAM showed that it is safe for human skin and eyes. LHE is proven to be safe and effective as active ingredient in cosmetic.
 
Index Terms
—cosmetic, Hibiscus rosa-sinensis, Lansium domesticum, lightening

Cite:Kilala Tilaar, Maily, Fransiska Devi Junardy, Erna Subroto, and Diah Puspitosari"Safety and Efficacy Evaluation on Combination of Lansium domesticum Fruit Extract and Hibiscus rosa-sinensis Flower Extract as Lightening Agent for Cosmetic," International Journal of Pharma Medicine and Biological Sciences, Vol. 7, No. 3, pp. 67-70, July 2018. doi: 10.18178/ijpmbs.7.3.67-70
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