Abstract—Arsenic (As) is a common and conspicuous toxicant. The tissue distribution and correlation between tissues for copper was assessed in male C57Bl/6 mice exposed to 0, 50, 500, or 5000 ppb arsenic in their drinking water for 3 weeks. The copper concentration in blood increased linearly with increasing arsenic doses, whereas the copper concentration in liver or kidney decreased linearly with respect to the dose applied.  These results indicate that there may be tissue difference in the disturbed levels of copper in the mice blood, liver, and kidney by subchronic exposure to arsenic in drinking water.
 
Index Terms—arsenic, copper, drinking water, mice