Abstract—The Microbiological quality of the following eye drops, gentamicin, chloramphenical, ciloxan and sulphacetamide was studied. Gentamicin, chloramphenicol and ciloxan products were sterile while sulphacetamide products were contaminated by Staphylococcus spp (16.7%) and Bacillus spp (66.7%). The mean aerobic count found in sulphacetamide was 3 x 10 ^2-C cfu/mL. This observation probably implies that eye drops sulphacetamide products could cause more health risk. However, hygienic practices of eye-drops, proper bottle design and training of patients could influence their microbial contaminations.