Abstract—CRP is an acute phase protein whose levels increase with the infection and inflammation. The present study was conducted at Victoria Hospital Bangalore, where a total of 171 HIV patients were enrolled with a note on their opportunistic infections (OI), CRP level and treatment history of the underlying OI. 58 asymptomatic patients acted as control with CRP level less than 6 mg/L, showing no base line rise in CRP. Of the 86 tuberculosis patients, 23 had no history of treatment and CRP was found to be 41.2 mg/L. 3 patients of TB, with 1 day treatment history, had a mean CRP of about 36.6mg/L. 6 patients of TB, with a treatment history of 2days, showed a mean CRP of about 17 mg/L. 7 patients with 3 days treatment history, showed a mean CRP of 10.7mg/L. A graph of CRP and no of days of treatment, showed a negative correlation (r = ¨C0.2427) between them. Graphically it was found that, CRP elevated on or after 23 days of treatment of underlying OI could indicatetreatment failure. CRP can be used as an indicator for the treatment response of the underlying OI in HIV positive patients.