Abstract—Natural hard tissues, including bone and tooth enamel, are not simple inorganic substances, but organic‑inorganic composites formed via inorganic mineral deposition regulated by biological macromolecules. Biomineralization technology imitates such biological processes. Under mild reaction conditions, mineral phases grow on organic templates, yielding repair materials whose chemical compositions and microstructures closely resemble native biological tissues. Incorporating functional ions such as magnesium, strontium, copper, zinc, and silver into biomineralized materials can endow these substrates with multiple biological properties: osteogenic capacity, pro‑angiogenic effect, antibacterial activity, and immunomodulatory potential. These modified materials therefore hold great application prospects in tissue repair and regenerative medicine. Centered on function‑ion‑modified biomineralized materials, this paper reviews existing research from fundamental theories, fabrication strategies, performance‑related mechanisms, and biomedical application perspectives. Current technical bottlenecks and prospective research directions are also discussed.
 
Keywords—biomimetic mineralization, organic‑inorganic composite biomaterials, tissue regeneration, controllable ion release, biomedical application

Cite: Manqing Cao, "Research Progress on Construction and Biomedical Applications of Function–ion–modified Biomineralized Materials," International Journal of Pharma Medicine and Biological Sciences, Vol. 15, No. 4, pp. 171-176, 2026.

Copyright © 2026 by the authors. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).