Abstract—Though sleep helps to consolidate recent memories, it is unknown whether later undisturbed sleep can compensate for the negative effects of disrupting the initial post-learning Rapid Eye Movement (REM) sleep. This research proposal will compare three different sleep conditions: normal sleep, optogenetic silencing of young adult-born neurons during REM sleep, and REM sleep disruption after one day of Morris water maze training. Memory will be tested using the Morris Water Maze test, and memory consolidation will be tested after different undisturbing recovery sleep. The prediction is that both adult born neuron silencing and REM sleep disruption will impair memory compared with the control group, but the young ABN silencing group is expected to recover their impaired memory faster than the disrupted REM sleep group.
 
Keywords—Rapid Eye Movement (REM) sleep, hippocampus, young adult born neuron, memory consolidation

Cite: Hongkai Qiu, "Effects of Recovery Sleep on Memory Consolidation in Mice after REM Sleep Manipulation," International Journal of Pharma Medicine and Biological Sciences, Vol. 15, No. 4, pp. 129-133, 2026.

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