1. How to submit my research paper? What’s the process of publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
2. Can I submit an abstract?
The journal publishes full research papers.[Read More]
IJPMBS 2023 Vol.12(4): 61-69
doi: 10.18178/ijpmbs.12.4.61-69

Computational Identification of Candidate Genes Involved in the Inflammation Pathway of AGE-RAGE Signaling in Lung Cancer Invasiveness

Grace Wang1,* and Yongsheng Bai2
1. Del Norte High School, San Diego, CA, USA
2. Next-Gen Intelligent Science Training, Ann Arbor, MI, USA
*Correspondence: gracewang187@gmail.com (G.W.)

Manuscript received January 19, 2023; revised February 22, 2023; accepted July 18, 2023.

Abstract—Due to its high mortality rate, cancer has been at the forefront of biomedical research. Specifically, lung cancer has been an ongoing public health problem as it accounts for the highest number of cancer deaths worldwide. Phenotypic expressions such as the invasiveness of lung cancer can vary among individuals. Studies have shown a strong correlation between lung cancer invasiveness and inflammation pathways, making inflammation an ideal biomarker for lung cancer diagnostics and a target for therapeutics. The AGE-RAGE signaling pathway, which causes inflammation by genes with differential expression, is one such pathway for inflammation. Typical causing factors include but are not limited to reactive oxygen species, miRNA targets, mutational signatures, and other pathological functions. Even though the AGE-RAGE inflammation pathway is influential in cancer, it has not yet been developed in therapeutics for cancer invasiveness and should be further studied. In this study, we evaluated the complexities of the AGE-RAGE pathway expression in cancer. Through a detailed investigation using online genomics databases, bioinformatics data analysis, and literature review, the role of inflammation is systematically explored. We also examined the implications of the upregulation of AGE-RAGE on other pathological functions and diseases. 
Keywords—AGE-RAGE, cancer, inflammation, miRNA

Cite: Grace Wang and Yongsheng Bai, "Computational Identification of Candidate Genes Involved in the Inflammation Pathway of AGE-RAGE Signaling in Lung Cancer Invasiveness," International Journal of Pharma Medicine and Biological Sciences, Vol. 12, No. 4, pp. 61-69, October 2023. doi: 10.18178/ijpmbs.12.4.61-69

Copyright © 2023 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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