1. How to submit my research paper? What’s the process of publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
2. Can I submit an abstract?
The journal publishes full research papers.[Read More]
IJPMBS 2023 Vol.12(4): 48-53
doi: 10.18178/ijpmbs.12.4.48-53

Bioinformatics-Based Analysis of Circulating Tumor Cells: A Methodological Overview of Personalized Cancer Treatment

Volkan Uslan1, Ludmilla Thomé Domingos Chinen2, and Huseyin Seker3,*
1. Department of Management Information Systems, Piri Reis University, Istanbul, Turkey
2. Instituto Brasileiro de Controle do Cancer, São Paulo-SP, Brazil
3. Faculty of CEBE, Birmingham City University, Birmingham, United Kingdom
*Correspondence: Huseyin.Seker@bcu.ac.uk (H.S.)

Manuscript received July 11, 2023; revised August 14, 2023; accepted August 30, 2023.

Abstract—Circulating Tumor Cells (CTCs) are capable of providing valuable insights throughout the course of a patient’s disease, even during the early stages of cancer. CTCs have recently gained significant interest for their potential for advancing personalized cancer treatment studies. Despite the challenges associated with their detection and analysis, emerging bioinformatics methodologies and technologies have enhanced the understanding of these cells and their role in cancer metastasis. This paper provides a methodological overview of these bioinformatics methodologies, particularly focusing on the computational analysis of CTCs and its implications for personalized cancer treatment strategies. Additionally, the paper highlights the importance of refining current techniques and need for a further development to overcome the limitations of liquid biopsies, such as their limited sensitivity in detecting low-abundance biomolecules. With this overview, we aim to show the transformative potential of CTC analysis combined with bioinformatics, providing valuable insights for future research and clinical applications in cancer immunotherapy and personalized medicine.
Keywords—circulating tumor cells, analysis of CTCs, cancer immunotherapy, personalized cancer treatment, bioinformatics-based analysis 
Cite: Volkan Uslan, Ludmilla Thomé Domingos Chinen, and Huseyin Seker, "Bioinformatics-Based Analysis of Circulating Tumor Cells: A Methodological Overview of Personalized Cancer Treatment," International Journal of Pharma Medicine and Biological Sciences, Vol. 12, No. 4, pp. 48-53, October 2023. doi: 10.18178/ijpmbs.12.4.48-53

Copyright © 2023 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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