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Enhancement Vehicles of Cardene Loading Poly(D,L-lactic-co-glycolic acid) Nanoparticles in Vitro Controlled Release for Biomedical Application

Nopparuj Soomherun1, Narumol Kreua-ongarjnukool1, Saowapa Thumsing Niyomthai1, and Sorayouth Chumnanvej2
1. Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, Thailand
2. Neurosurgery Unit, Surgery Department, Faculty of Medicine Ramathibodi Hospital Mahidol University, Bangkok, Thailand

Abstract—The goal of this research was to prepare a nanovehicles from Poly(D,L-Lactic-co-glycolic Acid) Nanoparticles (PLGA NPs) for delivering cardene. The cardene loading-PLGA NPs were fabricated by double emulsion and solvent evaporation process. PLGA has a monstrous interest to fabricate nanoparticles due to its good biodegradability and excellent biocompatibility. Drug loading and release profiles were performed as the model drug. The results appeared that cardene amount from 5.0 mg to 30.0 mg lead to the increase of the particle size, Polydispersity Index (PDI), and nanoparticle yield. The drug encapsulation efficiency was approximately 77% to 92%. The in vitro release from PLGA NPs was prolonged cardene concentration at periods more than 16 to 41 days. The cumulative drug release was a maximum of 40% to 70%. Moreover, the nanoparticles could be demonstrated biocompatible with the keratinocyte cells by MTT assay. The cardene loading-PLGA NPs were able to protect drug degradation and improve pharmacokinetics during transporting to the targeted organ. The cardene loading-PLGA NPs could be applied to prolonged drug delivery in biomedical applications.

Index Terms—poly(D,L-lactic-co-glycolic acid), cardene, nanoparticles, controlled release

Cite: Nopparuj Soomherun, Narumol Kreua-ongarjnukool, Saowapa Thumsing Niyomthai, and Sorayouth Chumnanvej, "Enhancement Vehicles of Cardene Loading Poly(D,L-lactic-co-glycolic acid) Nanoparticles in Vitro Controlled Release for Biomedical Application," International Journal of Pharma Medicine and Biological Sciences, Vol. 10, No. 1, pp. 1-7, January 2021. doi: 10.18178/ijpmbs.10.1.1-7

Copyright © 2021 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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