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A Collagen Formula for Anti-aging

Shu-Ting Chang1, Yung-Hsiang Lin1, Chen-Meng Kuan1, Kai-Wen Kan2, and Yung-Kai Lin3,4
1.Research & Design Center, TCI CO., Ltd., Taipei 114, Taiwan
2.Research & Design Center, TCI Gene Inc., Taipei, Taiwan
3.Institute of Food Safety and Risk Management, National Taiwan Ocean University, Keelung City 202, Taiwan
3.Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung 402, Taiwan

AbstractThis article demonstrates the synergistic effect of a collagen formula drink on improvement in Extracellular Matrix (ECM) protein synthesis and down-regulation of the collagen degradation gene and Reactive Oxygen Species (ROS) formation in human fibroblasts. The collagen formula drink mainly consists of porcine and fish collagens, which is an uncommon approach to skin repair and anti-aging. The collagen formula drink could enhance the collagen and elastin formation in UVA-treated CCD-966SK cells by 30% and 19%, respectively. In addition, it up-regulated collagen- and hyaluronate (HA)-associated genes (COL1A1, COL1A2, LOX, and HAS2) in the range of 75%-187% as well as down-regulated collagen-degradation gene (MMP-1) by 41%. Also, the collagen formula drink lowered the ROS formation in CCD-966SK cells by 26%. Accordingly, the collagen formula drink can substantially improve the skin repair efficiency after photodamage and provide a comprehensive protection effect on anti-aging.

Index Terms—porcine collagen, fish collagen, anti-aging, collagen, elastin, ROS

Cite:Shu-Ting Chang, Yung-Hsiang Lin, Chen-Meng Kuan, Kai-Wen Kan, and Yung-Kai Lin, "A Collagen Formula for Anti-aging," International Journal of Pharma Medicine and Biological Sciences, Vol. 9, No. 4, pp. 175-179, October 2020. doi: 10.18178/ijpmbs.9.4.175-179

Copyright © 2020 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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