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Piper sarmentosum Maintains Blood Pressure and Morphological Integrity of Liver in Type 1 Diabetic Rats

Zar Chi Thent and Srijit Das
Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur

Abstract—Piper sarmentosum (P.s) is known to possess anti-diabetic property and reduce the complications in diabetes mellitus (DM). In the present study, the effect of P.s extract on the blood pressure and liver tissue of experimental diabetic rats was determined. A total of 24 male Sprague-Dawley rats were used. Streptozotocin (STZ) was used for the induction of DM. Following, three days of STZ induction, the animals were equally divided (n=6) into; Ctrl: control, Ctrl+P.s: control with 0.125 g/kg of P.s, DM: untreated diabetic and DM+P.s: diabetic with 0.125 g/kg of P.s. The treatment with aqueous extract of P.s was continued for 28 days. At the end of the study, significantly decreased blood pressure and the morphological disturbances in liver tissue was reverted to normal in the DM+P.s group compared to the DM group. It is believed that P.s is an effective supplement for improving the organ damage in DM.

Index Terms—Piper sarmentosum, Diabetes mellitus, Liver tissue, Blood pressure.

Cite: Zar Chi Thent and Srijit Das, "Piper sarmentosum Maintains Blood Pressure and Morphological Integrity of Liver in Type 1 Diabetic Rats," International Journal of Pharma Medicine and Biological Sciences, Vol. 4, No. 1, pp. 24-28, January 2015.
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