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Formulation and Characterization of a Thalidomide Analogue in Nanoemulsion System

Noran M. Tawfik1,2, Mohammed Teiama3, Sameh Samir Iskandar4, Ahmed Osman1,5, and Sherif F. Hammad1,6
1.Biotechnology, Basic and Applied Sciences Institute, Egypt-Japan University of Science and Technology (E-JUST), Alexandria, Egypt
2.Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt
3.Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt
4.Surgical Oncology Department, Ismailia Teaching Oncology Hospital (GOTHI), Ismailia, Egypt
5.Department of Biochemistry, Faculty of Science, Ain shams University, Cairo, Egypt
6.Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt
AbstractThe objectives of the current study were to synthesize a thalidomide (THD) analogue and study its anticancer effect on human breast cancer cell line (MCF-7). Cytotoxic activity on the normal human cell line was assayed to ensure its safety on normal cells. It is quite a surprise to find that the synthesized analogue caused collapsing and shrinking in the shape of (MCF-7) while revealing its safety on the proliferation of normal human cell line. Therefore, it can be a promising compound in the treatment of breast cancer. Moreover, its encapsulation in a nanoemulsion system would enhances its potency. The plain nanoemulsion formula was evaluated by several characteristic methods, which showed that the mean droplet size was (345.6 nm) and mean zeta potential was (-9.98 mV). In addition to their examination under the field emission transmission electron microscope and noticed their spherical shape. Our future work is to study the drug entrapment efficiency and in vitro drug release. It is hoped that this study will lead to new insights of THD analogues as a therapeutic agent, particularly in the nanoemulsion system.
 
Index Terms—thalidomide analogue, anticancer activity, MTT assay, nanoemulsion, TEM

Cite: Noran M. Tawfik, Mohammed Teiama, Sameh Samir Iskandar, Ahmed Osman, and Sherif F. Hammad, "Formulation and Characterization of a Thalidomide Analogue in Nanoemulsion System," International Journal of Pharma Medicine and Biological Sciences, Vol. 11, No. 2, pp. 43-47, April 2022. doi: 10.18178/ijpmbs.11.2.43-47

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