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Phycocyanobilin: A Potential Anticancer Therapy—A Tale of a Natural Chromophore

Suzan A. Rashed1,2, Ahmed Osman1,3, Sherif F. Hammad1,4, Moustafa M. Eldakak5, and Islam A. Khalil6
1.Biotechnology Department, Institute of Basic and Applied Sciences, Egypt-Japan University of Science and Technology, Egypt
2.Botany and Microbiology Department, Faculty of Science, Alexandria University, Egypt
3.Biochemistry Department, Faculty of Science, Ain Shams University, Egypt
4.Pharmaceutical Chemistry Department, Faculty of Pharmacy, Helwan University, Egypt
5.Cell Biology Department, Faculty of Agriculture, Alexandria University, Egypt
6.Pharmaceutics Department, Faculty of Pharmacy and Drug Manufacturing, Misr University for Science and Technology, Egypt
AbstractBack to nature is a general theme for many research lines nowadays, where several substances that are extracted from natural sources have shown great potential in treating many diseases. Algal compounds, in particular, have drawn significant attention for being of biological importance. As cancer is one of the most diseases which causes people to suffer, all researchers and scientists exert much effort to end that suffering. Unfortunately, almost all the current applied conventional treatment methods exert serious side effects with limited therapeutic abilities. Recently, several algal value-added substances exhibited anticancer potentiality; they can be a promising alternative for cancer treatment. We extracted phycocyanin, a blue biliprotein, from Spirulina platensis SAM2021, with content 3.11 mg/ml and purity 0.61. The obtained phycocyanobilin by methanolysis cleavage showed maximum absorption at λmax= 600 nm. It exhibited IC50 108 μg/ml for colorectal cancer cell line HT-29.
Index Terms—algae, cancer, phycocyanobilin, phycocyanin, Spirulina, anticance

Cite: Suzan A. Rashed, Ahmed Osman, Sherif F. Hammad, Moustafa M. Eldakak, and Islam A. Khalil, "Phycocyanobilin: A Potential Anticancer Therapy—A Tale of a Natural Chromophore," International Journal of Pharma Medicine and Biological Sciences, Vol. 11, No. 2, pp. 30-35, April 2022. doi: 10.18178/ijpmbs.11.2.30-35

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