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In Vivo Genotoxicity Testing of Sesbania grandiflora (Katuray) Flower Methanol Extract

Levylee G. Bautista, Dawn Grace E. Santos, Ghafoor A. Haque, Jr. I, Aishwarya V. Veluchamy, Jesusa E. Santos, and Rodolfo T. Rafael
College of Medicine, Lyceum Northwestern University – Francisco Q. Duque Medical Foundation, Dagupan City, Philippines
AbstractThe booming interest in using natural compounds as an alternative to conventional medications has paved way to focus the attention on plants that provide rich sources of bioactive phytochemicals. For regulatory purposes, evaluation of the genotoxic and cytotoxic effects of such alternatives is therefore empirical as part of the plant’s hazard assessment. Sesbania grandiflora is among the plants used as a traditional remedy in folk medicine and a subject of research for its medicinal benefits. This study aimed to evaluate the genotoxic potential induced by S. grandiflora Flower Methanol Extract (SGFME) in terms of the frequency of Micronucleus Polychromatic Erythrocyte (MNPCE) and PCE ratio employing the micronucleus assay. The frequency of MN was examined in Bone Marrow Cells (BMCs) obtained from male Swiss albino mice exposed in vivo to four different concentrations (11.25, 22.5, 40, and 90 mg/kg) of SGFME and MMC (70 mg/kg; positive control) and sacrificed 24 h post-intraperitoneal injection. Results showed a significant (p < 0.01) rate of MNPCEs for 11.25 and 22.5 tested concentrations of SGFME and is comparable with the MMC-treated mice. Although PCE ratio values in all doses of SGFME-treated mice were over 0.20, it is worth noting that 40 and 90 tested concentrations of SGFME-treated mice exhibited the lowest value, i.e., 0.22 and 0.28, respectively. The present study has demonstrated that S. grandiflora possesses genotoxic potential for murine BMCs. This activity could be ascribed from the bioactive compounds present in S. grandiflora that require further isolation and characterization of the active molecules.
 
Index Terms—genotoxicity, micronucleus, phytochemicals, Sesbania grandiflora

Cite: Levylee G. Bautista, Dawn Grace E. Santos, Ghafoor A. Haque, Jr. I, Aishwarya V. Veluchamy, Jesusa E. Santos, and Rodolfo T. Rafael, "In Vivo Genotoxicity Testing of Sesbania grandiflora (Katuray) Flower Methanol Extract," International Journal of Pharma Medicine and Biological Sciences, Vol. 11, No. 1, pp. 14-19, January 2022. doi: 10.18178/ijpmbs.11.1.14-19

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