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Synthesis of Solid Lipid Nanoparticles Containing CoenzymeQ10 and Vitamin E through Hot Homogenization Process

Sirapatsorn Chaiprateep1 and Parichart Naruphontjirakul2
1.Chemical Engineering, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand
2.Biological Engineering Program, Faculty of Engineering, King Mongkut’s University of Technology Thonburi, Bangkok, Thailand
Abstract—The aim of present work was to develop a new formulation of Solid Lipid Nanoparticles (SLNs) containing Coenzyme Q10 (CoQ10) and Vitamin E (VitE) for transdermal drug delivery application using hot homogenization process. Three different conditions without drug loading were modified for optimization. The optimum condition was further used to prepare VitE-loaded SLNs and CoQ10&VitE-loaded SLNs. All drug-free and drug-loaded nanoparticles were in a diameter size range of 100 to 200 nm. The mean diameter of drug-free SLNs, SLNs containing VitE, SLNs containing CoQ10&VitE were 135 ± 39, 141 ± 37 and 162 ± 46 nm, respectively. Monodispersed SLNs were successful prepared with Polydispersity Index (PDI) value (below 0.5). Zeta potential value was around 40 mV for all prepared particles providing a good physical stability. Except that of CoQ10&VitE-loaded particles, their zeta potential was around -60 mV. By UV-vis spectrophotometer, the encapsulation efficiency of VitE-loaded and CoQ10&VitE-loaded SLNs were nearly 100%. XRD analysis results showed amorphousness (broad peak) of the prepared nanoparticles (NPs).

Index Terms—solid lipid nanoparticles, coenzyme Q10, vitamin E, hot homogenization

Cite: Sirapatsorn Chaiprateep and Parichart Naruphontjirakul, "Synthesis of Solid Lipid Nanoparticles Containing CoenzymeQ10 and Vitamin E through Hot Homogenization Process," International Journal of Pharma Medicine and Biological Sciences, Vol. 10, No. 4, pp. 153-157, October 2021. doi: 10.18178/ijpmbs.10.4.153-157

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