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The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
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The journal publishes full research papers.[Read More]
 

Derivation and Progress of Non-enzymatic RNA Replication

Xinyu Wu
Beijing Jingshan School Caofeidian Branch International Department, Tangshan, China
Abstract—Molecular replication has branched into two parts, on one hand, it involves the non-informational copying of polymers which provides a replication environment indirectly, and on the other hand, the informational copying, including DNA or RNA replication, is a direct replication system. On account of the central dogma of molecular biology, after the transcription from DNA to mRNA, some living organisms require a specific RNA polymerase to catalyse and control the reaction of RNA self-replication. Based on the RNA world hypothesis, the self-replication of RNA at the earlier stage of the origin of life occurred under an enzyme-free condition. RNA replication process needs three steps: (a) separation of the duplex, (b) monomer extension of each strand, and (c) the end to end propagation of RNA strand. It was suggested that non-enzymatic RNA copying could take place in the presence of metal ions, like Mg2+ or Fe2+. Strand separation can be achieved by pH or temperature oscillation, and the RNA monomer extension could be attainable with the involvement of two activated nucleotides. This review gives a brief summary of the accomplishments scientists have made, and also concerns about several impediments in this process as well as their solutions.

Index Terms—divalent ions, imidazolium dinucleotide, RNA world, the origin of life

Cite: Xinyu Wu, "Derivation and Progress of Non-enzymatic RNA Replication," International Journal of Pharma Medicine and Biological Sciences, Vol. 10, No. 3, pp. 130-134, July 2021. doi: 10.18178/ijpmbs.10.3.130-134

Copyright © 2021 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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