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Study Kinetics Models of Clindamycin Hydrochloride from Poly(D,L-lactic-co-glycolic acid) Particles

Chatchawan Soonklang, Chalermchai Tassanarangsan, Nopparuj Soomherun, Narumol Kreua-ongarjnukool, and Saowapa Thumsing Niyomthai
Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok, Thailand
Abstract—The aim of this research is to study the kinetic models of Clindamycin hydrochloride encapsulated in poly(D,L- lactic-co-glycolic acid) particles (CLH/PLGA). The CLH/PLGA particles were prepared by the double emulsion technique. The characterizations of CLH/PLGA particles were determined particle size, zeta potential, encapsulation efficiency, morphology, principle functional group, swelling, and in vitro drug release profile. The morphology of CLH/PLGA particles was the smooth and spherical shape. The maximum encapsulation efficiency of CLH/PLGA particles was 75% and the particle size of CLH/PLGA particles is from 216 to 222 nm and zeta potential value from -14.7 to -12.76 mV. The in vitro release of CLH/PLGAparticles was carried out in pH 6.8 and pH 7.4. The modeldrug release profile result was fitting with the kineticmathematic model. In addition, the kinetic models ofCLH/PLGA particles released in pH 6.8 and pH 7.4 wereFirst order model and Korsmeyer-Peppas model. Theinvestigated of the kinetic model also gave a better of theeffect on the CLH release pattern.

Index Terms—poly(D,L-lactic-co-glycolic acid), clindamycin hydrochloride, nanoparticles, kinetic models

Cite: Chatchawan Soonklang, Chalermchai Tassanarangsan, Nopparuj Soomherun, Narumol, Kreua-ongarjnukool, and Saowapa Thumsing Niyomthai, "Study Kinetics Models of Clindamycin Hydrochloride from Poly(D,L-lactic-co-glycolic acid) Particles," International Journal of Pharma Medicine and Biological Sciences, Vol. 10, No. 2, pp. 68-74, April 2021. doi: 10.18178/ijpmbs.10.2.68-74

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