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Characterization and Stability Evaluation of Film-Forming Polymeric Solution Containing Clove Oil Microemulsion for Treatment of Cutaneous Candidiasis

Chaowalit Monton 1, Sukanya Settharaksa 1, and Jirapornchai Suksaeree 2
1.Drug and Herbal Product Research and Development Center, College of Pharmacy, Rangsit University, Pathum Thani, Thailand
2.Department of Pharmaceutical Chemistry, College of Pharmacy, Rangsit University, Pathum Thani, Thailand
AbstractThis work sought to prepare, characterize, and evaluate the stability of Film-Forming Polymeric Solution (FFPS) containing clove oil microemulsion. The ratio of film-forming polymers—Polyvinyl Alcohol (PVA) and hydroxypropyl methylcellulose (HPMC F4M)—were varied from 100:0 to 75:25. The developed FFPS containing clove oil microemulsion, which contained clove oil 1%, dried within 10-15 minutes and formed the complete film after drying. The pH of the formulations was approximately 4.8-4.9. The pH and spread ability values were increased, while the viscosity decreased when the ratio of HPMC F4M increased. The standard marker, eugenol, in the formulation was approximately 0.5%. The formulation exhibited a good anti-Candida albicans property; the inhibition zone was approximately 1.2 cm. Eugenol release from FFPS containing clove oil microemulsion showed the Korsmeyer-Peppas release model. Moreover, the release mechanism was anomalous transport. The anti-Candida albicans activity was stable for 60 days, but it was decreased at 90 days of the experiment when stored at 25 and 40ºC, except when stored at 4ºC, the anti-Candida albicans activity was not significantly different compared with at the initial time. In summary, the developed FFPS containing clove oil microemulsion was an alternative product that could be used for the treatment of cutaneous candidiasis.
 
Index Terms—film-forming polymeric solution, clove oil, microemulsion, cutaneous candidiasis
 
Cite:Chaowalit Monton, Sukanya Settharaksa, and Jirapornchai Suksaeree, "Characterization and Stability Evaluation of Film-Forming Polymeric Solution Containing Clove Oil Microemulsion for Treatment of Cutaneous Candidiasis," International Journal of Pharma Medicine and Biological Sciences, Vol. 9, No. 4, pp. 164-168, October 2020. doi: 10.18178/ijpmbs.9.4.164-168

Copyright © 2020 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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