Abstract—Tobacco specific nitrosamines are one of the most carcinogenic compounds present in the tobacco smoke. Studies have been conducted and multiple methods have been developed to detect and analyze the tobacco specific nitrosamines in order to understand their effects on human body. In recent years, researchers have developed and brought varies methods in drug analysis. The focus of this paper is the current status of Liquid Chromatography (LC), Capillary Electrophoresis (CE), Gas Chromatography (GC) coupled with Mass Spectrometry (MS) in the analysis of carcinogenic compounds in tobacco smoke. We have discussed the advantages and disadvantages of each method, as well as their applications in qualification and quantification of tobacco specific nitrosamines. By combining the conventional methods of LC-MS, CE and GC-MS, together with the newly-developed fields of nanomaterials and metabolomics, scientists are able to effectively quantify and analyze different carcinogens in tobacco smoke.
 

Index Terms—tobacco specific nitrosamines, carcinogenic compounds, chromatography- mass spectrometry, nanomaterials, metabolomics

Cite: Hanti Jiang, "Investigation of Carcinogenic Compounds in Tobacco Smoke," International Journal of Pharma Medicine and Biological Sciences, Vol. 9, No. 3, pp. 140-143, July 2020. doi: 10.18178/ijpmbs.9.3.140-143

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