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Effect of Triiodothyronine (T3) on Fast Troponin I, C, & T Protein Levels in Rat Soleus Muscle

Ronny Lesmana 1,2, Akbar Haqi 2, Hanna Goenawan 1,2, Rizky Abdulah 3, and Unang Supratman 2,4
1. Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Jatinangor, Indonesia
2. Physiology Molecular Laboratory, Biological Activity Division, Central Laboratory, Universitas Padjadjaran, Jatinangor, Indonesia
3. Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia
4. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, Indonesia
Abstract—Troponin complex is essentially situated on slim fiber of striated muscle and control connection of slight and thick fiber and it might be affected by Triiodothyronine (T3). Unfortunately, there is limited study about regulation of T3 on troponin profile. In the present examination, we investigate and distinguish the impact of T3 to troponin proteins. Twelve male rat wistar, 12 weeks old were divided into 2 groups. Hyperthyroidism was induced by injecting T3 20-μg/100-g Body Weight (BW) for 10 days per intraperitoneal (i.p.). After sacrificed using CO2 chamber, rat soleus muscle were dissected out and stored at −80°C until use. T3 stimulated protein level of troponin I, T and and induce but not significant troponin C level in rat soleus muscle. T3 increase significantly the protein expression of Troponin I by 1,67 folds and Troponin T by 1,71 folds compare to control groups. In the other hand, we observed that T3 trend to stimulate the troponin C protein levels although not statistically significant. It seems that troponin C might less sensitive in response to T3 induction. Taken together, T3 alters troponin profile of soleus muscle which it might affect muscle performance.
Index Terms—Triiodothyronine, troponin I, troponin C, troponin T and soleus muscle

Cite: Ronny Lesmana, Akbar Haqi, Hanna Goenawan, Rizky Abdulah, and Unang Supratman, "Effect of Triiodothyronine (T3) on Fast Troponin I, C, & T Protein Levels in Rat Soleus Muscle," International Journal of Pharma Medicine and Biological Sciences, Vol. 9, No. 3, pp. 102-106, July 2020. doi: 10.18178/ijpmbs.9.3.102-106

Copyright © 2020 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.
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