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Genetic Mutations Associated with Diffuse Large B-Cell Lymphoma

Jinghan Qiu1 and Pingzhang Wang2
1.Rutgers Preparatory School, Somerset, United States
2.Peking University, China
Abstract—Diffuse Large B-Cell Lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL) among adults. [1] A cancer of B cells, DLBCL can arise in any part of the body. [2] Although DLBCL is not well understood and classified right now, substantial credible clinical data took by authoritative organizations are available online. Online clinical data related to DLBCL include data of mutated gene, high sequence, gene expression, copy number, etc. Here, utilizing clinical data, the researcher finds the most frequently mutated genes, and by analyzing the llluminaHiSeq in TCGA DLBCL data set, the researcher finds eleven frequently mutated genes that have significant effect on certain genes’ expression once mutated (ARID1A, HIST1H1E, MGA, ATM, SGK1, IRF8, TET2, BTG2, EP300, CHD8, MLL2). If these eleven genes’ mutation can be controlled by medical therapies, patients with DLBCL may be treated because of the reducing irregular gene expressions.

Index Terms—genetic mutations, Diffuse Large B-Cell Lymphoma (DLBCL), gene regulation, database

Cite:Jinghan Qiu and Pingzhang Wang, "Genetic Mutations Associated with Diffuse Large B-Cell Lymphoma," International Journal of Pharma Medicine and Biological Sciences, Vol. 9, No. 2, pp. 87-90, April 2020. doi: 10.18178/ijpmbs.9.2.87-90

Copyright © 2020 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.

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