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The Role of Complement in the Treatment of Tumor Diseases

J. K. Ukibayev1, I. A. Franceva2, U. M. Datkhayev1, A. P. Francev2, T. G. Goncharova3, V. K. Krasnoshtanov3, and D. A. Myrzakozha1
1.Kazakh National Medical University named after S.D. Asfendiyarov, Almaty, 050010, Kazakhstan
2.Research and Production Association “Fran”, Almaty, 050010, Kazakhstan
3.Kazakh Research Institute of Oncology and Radiology, Almaty, 050010, Kazakhstan
Abstract—The phenomenon of antibody is dependent on the cell in which occurs the main mechanism of action of all targeted antitumor preparations containing monoclonal or polyclonal antibodies. Successful manifestation of this phenomenon is possible only with the correct ratio between the antigens of cancer cells, antibodies specific to them and the required amount of complement. The following paper shows the need to monitor the quantitative content of complement in the patient's serum and correct its content by introducing the required volume of fresh frozen plasma as a source of exogenous complement. The required amount of specific antibodies (dosage of the drug) must be determined after proper correction of the amount of complement in the patient's blood. If this condition is met, the maximum efficacy of the drug and the increased success of the treatment of tumor diseases will be achieved.

Index Terms—complement, antibody, antitumor activity, serum

Cite:J. K. Ukibayev, I. A. Franceva, U. M. Datkhayev, A. P. Francev, T. G. Goncharova, V. K. Krasnoshtanov, and D. A. Myrzakozha, "The Role of Complement in the Treatment of Tumor Diseases," International Journal of Pharma Medicine and Biological Sciences, Vol. 9, No. 2, pp. 60-64, April 2020. doi: 10.18178/ijpmbs.9.2.60-64

Copyright © 2020 by the authors. This is an open access article distributed under the Creative Commons Attribution License (CC BY-NC-ND 4.0), which permits use, distribution and reproduction in any medium, provided that the article is properly cited, the use is non-commercial and no modifications or adaptations are made.

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