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The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
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The journal publishes full research papers.[Read More]
 

A Novel Approach for Detecting Driver Mutated Pathways in Glioblastoma Multiform

Yassine EL Kati 1, Shu-Lin Wang 1, and Fouad Kharroubi 2
1. School of Computer Science and Electronic Engineering, Hunan University, Changsha, 410082, Hunan, China
2. Ecole Nationale des Sciences Appliquées, ENSAJ, LTI Lab, Chouaib Doukkali University, El Jadida, 24002, Morocco
Abstract—Quite recently, considerable attention has been paid to finding the distinction between driver mutations that lead to tumorigenesis and passenger mutations that are neutral and do not play any role in the cancer proliferation. The main objective of this work is to come up with a new method to solve “The Maximum Weight Submatrix Problem”. To that end, we introduce a new constraint named “approximate exclusivity” that helps to determine precisely the number of mutations that each patient has in the pathway. Depending on this constraint, we present a novel algorithm that detects driver mutated pathways based on an exact approach. We describe the details about our algorithm, then we compare the results with a Genetic Algorithm and a Binary Linear Programming model in both simulated and genetic data. Our exact algorithm has shown a good performance in terms of maximizing the weight and detecting all the possible driver pathways.
 
Index Terms
—driver pathways, maximum weight submatrix problem, exact algorithm, genetic algorithm, binary linear programming, glioblastoma multiform

Cite:Yassine EL Kati, Shu-Lin Wang, and Fouad Kharroubi"A Novel Approach for Detecting Driver Mutated Pathways in Glioblastoma Multiform," International Journal of Pharma Medicine and Biological Sciences, Vol. 8, No. 1, pp. 17-21, January 2019. doi: 10.18178/ijpmbs.8.1.17-21

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