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The Effect of Salbutamol towards Heart Rate in Neutrophilic and Eosinophilic Asthma Patient

Hanif Purbaya, Moch. Rizki Efendi, Afief Mulyawijaya, and Adika Zhulhi Arjana
Faculty of Medicine, Universitas Islam Indonesia, Yogyakarta, Indonesia
Abstract—Asthma is categorized into eosinophilic and neutrophilic subtypes based on its blood profile characteristic and each subtypes tend to have different severity. Salbutamol is a first choice drug which used for asthma patients in Indonesia.. Salbutamol leads to a smooth muscle relaxation and bronchodilation. In addition to bronchodilation, salbutamol inhibits the release of bronchoconstricting agents. Salbutamol’s administration has tachycardia adverse effect. Since asthma subtypes have different severity, salbutamol’s administration might have different result towards each subtypes.This study used retrospective cross-sectional study. We compiled medical records of asthma patient in General Hospital of Kebumen (RSUD Kebumen), Indonesia. Inclusion criteria for the subject is asthma patient in 2016 and exclusion criteria for the study is incomplete medical records data. We successfully obtained 47 medical records to be our subject and were grouped into two groups based on their blood profile characteristic. Ten patients were grouped into eosinophilic asthma and 37 patients were grouped into neutrophilic asthma. We took demographical data from our subjects including age, sex, vital sign, and blood profile. The T-test of age for both asthma groups showed the result of p< 0.05 (0,017) which means there is difference of age on the division of asthma group. Fisher’s Exact test of association between gender asthma groups showed the result p = 0.499 which means there is no significant differences of gender on the division of asthma group. Heart rate ratio and asthma group that were tested using independent test T-test  showed the result of p> 0.05 (p = 0.278) which means no effect of using salbutamol as asthma therapy to increase the heart rate in patient subject of asthma.There was no association between the use of salbutamol in asthmatic patients with an increase in heart rate for either eosinophilic asthma or neutrophilic asthma.  
 
Index Terms
—asthma, salbutamol, tachycardia, eosinophilic, neutrophilic

Cite: Hanif Purbaya, Moch. Rizki Efendi, Afief Mulyawijaya, and Adika Zhulhi Arjana"The Effect of Salbutamol towards Heart Rate in Neutrophilic and Eosinophilic Asthma Patient," International Journal of Pharma Medicine and Biological Sciences, Vol. 7, No. 4, pp. 88-91, October 2018. doi: 10.18178/ijpmbs.7.4.88-91

 
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