1. How to submit my research paper? What’s the process of publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
2. Can I submit an abstract?
The journal publishes full research papers.[Read More]
 

Human Gut Microbiome Analysis and Multi-omics Approach

Tiziana Maria Sirangelo
Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy
 Abstract—Given the importance of human gut microbioma in human health, its role has been recently reviewed and even now is the subject of many investigations. It is known that traditional culture methods are limited for analyzing it and that high-throughput sequencing, omics technologies instead allow to deepen the behaviour of microbial ecology. With the application of omics technologies, as metagenomics, metascriptomics, metaproteomics and metabolomics, many progress has been made in this field. Their integration, referred to as multi-omics approach, provides more evidence for biological mechanisms. This review highlights that omics approaches can be powerful tools in analyzing the human gut microbiome.  The current scenario and examples of recently published landmark work are discussed and some limitations are outlined. Their combination is analyzed and relevant studies allowing us to link the expression of disease-associated microbial functions to distinct taxa are treated. Furthermore, recent system level approaches for integrating different omics layers are discussed and some researches aimed to develop a framework for the reconstruction of a large microbial community are examined. However, even today, we are aware that the multi-layer datasets integration is a challenging issue and that a careful planning of a multi-omics application is thus required.
 
Index Terms—metagenomics, metatranscriptomics, human gut microbiome, metaproteomics, metabolomics

Cite:Tiziana Maria Sirangelo"Human Gut Microbiome Analysis and Multi-omics Approach," International Journal of Pharma Medicine and Biological Sciences, Vol. 7, No. 3, pp. 52-57, July 2018. doi: 10.18178/ijpmbs.7.3.52-57

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