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Antibiotics Efficacy Analysis on Diabetic Foot Ulcer Inpatients

Irma Susanti 1, Bambang Arianto 2, and Anita Purnamayanti 1
1. Faculty of Pharmacy, University of Surabaya, Indonesia
2. Department of Surgery, Haji General Hospital Surabaya, Indonesia
Abstract—Introduction: Diabetic foot ulcer known as infection, ulceration or destruction of deep tissues associated with neurological abnormalities and various degrees of peripheral vascular diseases in lower limb. Treatment of diabetic foot ulcer required intensive empiric and definitive antibiotic therapies. Beside antibiotic, there are other factors that influence the diabetic foot ulcers healing. This study aims to determine the relationship between suitability and efficacy of antibiotics to wound improvement and other factors influence for wound improvement. Methods: This prospective cohort study was perform in Haji General Hospital Surabaya since June until August 2015 on 17 diabetic foot ulcer inpatients age ≥20 years old. Suitability of empiric antibiotic was compared to hospital standard procedure and suitability of definitif antibiotic was compared to the result of microbial culture and sensitivity test of each patient. Result: The relationship between suitability of empiric antibiotics and other factors influence for wound improvement could not be analized by inferential statistic because of limited data variation.The relationship between suitability and efficacy of definitive antibiotics to wound improvement was not significant (13,1%, p=0,585). Other factors beside antibiotics which significantly associated with wound improvement was debridement in surgery room 66,2% (p=0,000). Conclutions: Suitability of antibiotics was not the most influence on the process of improvement in diabetic foot ulcer. The most important factor for wound improvement was debridement in operation room.

Index Terms—suitability, efficacy, antibiotic, diabetic foot ulcer, inpatient

Cite: Irma Susanti, Bambang Arianto, and Anita Purnamayanti, "Antibiotics Efficacy Analysis on Diabetic Foot Ulcer Inpatients," International Journal of Pharma Medicine and Biological Sciences, Vol. 5, No. 4, pp. 232-236, Octorber 2016. doi: 10.18178/ijpmbs.5.4.232-236

 
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