Abstract—There is no research currently exist about the use of ceftriaxone as perioverative antibiotics for appendicitis patient in Haji General Hospital Surabaya, so its relationship with the surgical wound after appendectomy is remain unknown. This research is conducted to determine the suitability and efficacy of ceftriaxone, also to identify other factors that influence the surgical wound. This was a prospective cohort study of 25 patients (age ≥ 15 years old) between June–August 2015. The specimens culture demonstrated that 12 bacteria were E. coli, 1 ESBL-producing E. coli and 12 negative. Antibiotics susceptibility testing showed that 41,67% E. coli was susceptible to ceftriaxone. There was no significant relationship between suitability of postoperative antibiotics and surgical wound after appendectomy in non-perforated cases (p=0,505), while perforated case defined a significant relationship (p=0,011). The factors which significantly related with surgical wound were gender (p=0,014) and duration of surgery (p=0,017). Ceftriaxone was still effective as perioperative antibiotics. Postoperative antibiotics were only required for perforated appendicitis, whereas prophylactic antibiotic was known to be adequate in the case of non-perforated.