Abstract—The exact mechanism of how various proteins translocate from the extracellular into the nucleus to initiate cancer evolution is not known. Specific sequence associated with such nuclear event, thus known as Nuclear Localization Signal (NLS) was investigated. MATRIX Metalloproteinase (MMP) family proteins were found to possess NLS. Research shows over expression of the nuclear MMP(7) protein in different types of human cancer. It is claimed that animals have acquired better pathways to overcome tumor development, therefore it is vital to focus on cancer evolution. The aim of this paper is to investigate evolutionary origin of the NLS in MMP7 by analyzing different species. We found MMP NLS is much conserved but with variations and MMP7 NLS shows the partial consistence with Full-length protein in different species. Our data suggest that nuclear MMP may have undergone evolutionary deviation during natural selection for cancer development.
 

Index Terms—MMP7, nuclear MMP7, NLS, putative NLS, cancer evolution, cladogram

Cite: Diyora Abdukhakimova and Yingqiu Xie,  "Comparative Analysis of NLS Sequence Suggests the Evolutionary Origin of Nuclear Matrix Metalloproteinase 7 during Cancer Evolution," International Journal of Pharma Medicine and Biological Sciences, Vol. 5, No. 4, pp. 206-210, Octorber 2016. doi: 10.18178/ijpmbs.5.4.206-210