Abstract—This study was conducted in AL-Zahraa general hospital in Al-kut city/ Iraq. To assess serum urea, creatinine, lipid profile (cholesterol, TG, DHL and LDL) and thyroid hormones (FT3, FT4 and TSH) in chronic renal failure (CRF) patients it included 50 patients, 29 were males and 21 were females and their age range from 20 to 60 years. The control groups were 30; who were free from signs and symptoms of renal disease, lipid disorders, and thyroid hormones disorders, 20 were males and 10 were females, and their ages range from22 to 66 years. The study shows that the Serum urea and creatinine concentrations in CRF patients were found to be significantly high compared with control group (P<0.001), Serum triglycerides concentrations in CRF patients were found to be normal or no significantly increase compared with control group (P> 0.05), Serum cholesterol, HDL and LDL concentrations in CRF patients were found to be no significantly lower compared with control group, Serum FT3, FT4 and TSH concentrations in CRF patients were found to be no significantly lower compared with control group and No significant relationship between lipid profiles concentrations changes and thyroid hormones concentrations changes were found.