1. How to submit my research paper? What’s the process of publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
2. Can I submit an abstract?
The journal publishes full research papers.[Read More]

Comparative Molecular Simulation Method for Ang2/Aptamers with in vitro Studies

Jangam Vikram Kumar1, Jeffrey J. P. Tsai1, Wen-Pin Hu1 and Wen-Yih Chen2
1 Department of Biomedical Informatics/Asia University, Taichung City, 41354, Taiwanbr /> 2 Department of Chemical and Materials Engineering/National Central University, Jhong-Li City, 32001, Taiwan
Abstract—Many researchers have reported about angiopoietin-2 (Ang2), which plays vital aspect of tumor Angiogenesis. Literature studies confirm that aptamers generated by in vitro selection strategy (systematic evolution of ligands by exponential enrichment, SELEX) has the ability to bind and inhibit Ang2 in vitro. A comparative simulation was performed between aptamers and Ang2 in computational environment using Discovery Studio 3.5. ZDOCK which uses Pairwise Shape Complementary as scoring function was performed for simulation, along with ZRANK which assess accurately reranking the rigid body docking results from ZDOCK. From this approach, our computational results showed consistent to in vitro results, thus providing ZDOCK with ZRANK as an alternative method for computational selection of best binding aptamers. This study also presents the binding interface between Ang2/aptamers which can be informative in the future study.

Index Terms—Angiopoietin 2, aptamers, pairwise sequence complementary, molecular simulation

Cite: Jangam Vikram Kumar, Jeffrey J. P. Tsai, Wen-Pin Hu and Wen-Yih Chen, "Comparative Molecular Simulation Method for Ang2/Aptamers with in vitro Studies," International Journal of Pharma Medicine and Biological Sciences, Vol. 4, No. 1, pp. 61-64, January 2015.
Copyright © 2012-2019 International Journal of Pharma Medicine and Biological Sciences, All Rights Reserved
E-mail: ijpmbs@ejournal.net