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A Single Blind Randomized Study to Compare the Efficacy of Preemptive Analgesia of Ropivacaine Verses Bupivacaine for Post Tonsillectomy Pain Relief in Children

Mahadevappa Gudi 1 and Shiddalingesh Salimath 2
1 Department of Anaesthesiology and critical care, Akash Institute of Medical Sciences, Bangalore, India.
2 Department of Pharmacology, Karnataka Institute of Medical Sciences, Hubli, India.
Abstract—Pre-emptive analgesia is an effective tool to manage post surgical pain. We conducted the study to evaluate the efficacy of ropivacaine and bupivacaine for pre-emptive analgesia in patients undergoing tonsillectomy. AIMS : To compare the efficacy of pre incisional infiltration of tonsillar Fossa with 0.5% Ropivacaine with 1:5,00000 adrenaline verses 0.5% Bupivacaine with 1:5,00000 adrenaline on pain following tonsillectomy under general anaesthesia. PATIENTS AND METHODS: A total of 108 patients aged 7-18 years, ASA grade I & II, who came for tonsillectomy or adenotonsillectomy were recruited for the study. They were allotted randomly into two Groups. A Group (n= 54) patients received 0.5% Ropivacaine with 1:5,00000 adrenaline and patients in B Group (n = 54) were administered 0.5% Bupivacaine with 1:5,00000 adrenaline preoperatively 5 mins before the incision. Post operative pain was assessed by Visual Analogue scale (VAS), and Objective Pain Score (OPS) at 30 mins 1, 2, 4, 6, 8, 12 and 24 hrs and time of first request of analgesia. RESULTS : In both the Groups mean ops and VAS scores were comparable. The average time of first request of analgesic in group A was 80min while that in the Group B was 97min. Thus the degree of post operative pain relief in both the groups was comparable. CONCLUSION : Ropivacaine is as effective as bupivacaine in treating the post tonsillectomy pain.

Index Terms—Ropivacaine, Bupivacaine, Pre-emptive analgesia, Pain

Cite: Mahadevappa Gudi and Shiddalingesh Salimath, "A Single Blind Randomized Study to Compare the Efficacy of Preemptive Analgesia of Ropivacaine Verses Bupivacaine for Post Tonsillectomy Pain Relief in Children," International Journal of Pharma Medicine and Biological Sciences, Vol. 3, No. 4, pp. 70-76, October 2014.
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