1. How to submit my research paper? What’s the process of publication of my paper?
The journal receives submitted manuscripts via email only. Please submit your research paper in .doc or.pdf format to the submission email: ijpmbs@ejournal.net.
You’ll be given a paper number if your submission is successful. Your paper then will undergo peer review process, which may take approximately one and a half months under normal circumstances, three tops.
After blind peer review, you will receive the notification letter with the review result of your paper...
2. Can I submit an abstract?
The journal publishes full research papers.[Read More]
 

Epigenetics of Phorbol Esters, a Tumor Promoter and Differentiation Inducer

S R Sethu Narayanan
Inter-disciplinary Centre for Clinical Research (IZKF), University of Leipzig, Germany.
Abstract—Epigenetics is the study of structurally and functionally relevant molecular changes to the genome that do not constitute a change in the nucleotide sequence such as DNA methylation and histone modifications. These changes are involved in the expression and repression of different genes in a particular cell type. Phorbol esters are diterpene compound known as phorbol 12-myristate 13-acetate (PMA) or Tetradecanoylphorbol-13-acetate (TPA). They are routinely used to study the mechanism of signal transduction in tumor promotion and differentiation induction of different cell types. Recent work on the PMA has linked its function to the epigenetic changes in different cells. This review summarizes the epigenetic changes mediated by PMA and its role in the regulation of gene expression.

Index Terms—Phorbol esters, PMA, DNA methylation, Histone modifications, Acetylation, Methylation

Cite: S R Sethu Narayanan, "Epigenetics of Phorbol Esters, a Tumor Promoter and Differentiation Inducer," International Journal of Pharma Medicine and Biological Sciences, Vol. 3, No. 3, pp. 17-27, July 2014.
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