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A Comparative Study of Efficacy of Terbinafine and Fluconazole in Patients of Tinea Corporis

Kumar Amit 1, Budania Navin 2, Sharma Priyamvada 3, and Singh Monika 4
1 Department of Pharmacology, Major SD Singh Medical College, Farrukhabad, India.
2 Department of Pharmacology, S.H.K.M. Govt. Medical College, Mewat, Haryana, India.
3 Department of Pharmacology, S.N. Medical College, Agra, India.
4 Major SD Singh Medical College, Farrukhabad, India.
Abstract—Objectives: This study aimed to compare the efficacy of terbinafine and fluconazole in the treatment of Tinea corporis.Material and methods: Total 116 tinea corporis patients who were not responding to topical antifungal therapy of 2 weeks were selected and they were randomly divided into two groups. Group-I received oral terbinafine (250 mg) daily for 4 weeks. Group-II received oral fluconazole (150 mg) once weekly for 4 weeks. Evaluation is done by assessment of target symptoms, i.e., scaling, erythema, and pruritus (as clinical score 0 to 3) and by Clinical response rates at the end of treatment. Results: There was a significant decrease in the clinical score beginning from baseline to 4 th week in both the groups (P < 0.05). If we compare the clinical score of both the groups after 4 th week, there is slight more reduction of clinical score in group-I than of group-II (P > 0.05). The clinical response rate of group-I at 4 th week was 92.86%, whereas Clinical response rate of group-II was 82.00% (P > 0.05). Conclusion: Both fluconazole and terbinafine are quite effective in the treatment of tinea corporis patients in terms of clinical cure. Terbinafine shows slightly better results than fluconazole (P > 0.05).

Index Terms—Fluconazole, Terbinafine, Tinea corporis, Clinical response rate

Cite: Kumar Amit, Budania Navin, Sharma Priyamvada, and Singh Monika, "A Comparative Study of Efficacy of Terbinafine and Fluconazole in Patients of Tinea Corporis," International Journal of Pharma Medicine and Biological Sciences, Vol. 2, No. 4, pp. 92-96, October 2013.
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