Abstract—Objectives: This study aimed to compare the efficacy of terbinafine and fluconazole in the treatment of Tinea corporis.Material and methods: Total 116 tinea corporis patients who were not responding to topical antifungal therapy of 2 weeks were selected and they were randomly divided into two groups. Group-I received oral terbinafine (250 mg) daily for 4 weeks. Group-II received oral fluconazole (150 mg) once weekly for 4 weeks. Evaluation is done by assessment of target symptoms, i.e., scaling, erythema, and pruritus (as clinical score 0 to 3) and by Clinical response rates at the end of treatment. Results: There was a significant decrease in the clinical score beginning from baseline to 4 th week in both the groups (P < 0.05). If we compare the clinical score of both the groups after 4 th week, there is slight more reduction of clinical score in group-I than of group-II (P > 0.05). The clinical response rate of group-I at 4 th week was 92.86%, whereas Clinical response rate of group-II was 82.00% (P > 0.05). Conclusion: Both fluconazole and terbinafine are quite effective in the treatment of tinea corporis patients in terms of clinical cure. Terbinafine shows slightly better results than fluconazole (P > 0.05).