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Tumor Reducing and Anticarcinogenic Activity of Green Tea against Daltons Ascites Lymphoma Cells

B Geetha and K S Santhy
Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore, Tamil Nadu, India 641043
Abstract—The present study was carried out to evaluate the effect of Methanol Extract of Green Tea (MEGT) on Tumor growth and haematological parameters. After inoculation of DAL cells in to mice, treatment with MEGT (200 and 400 mg/kg) and standard drug 5-Fluorouracil (10 mg/kg) were continued for 9 days. The MEGT decreased the ascites fluid volume, viable cell count, and increased the non viable cell count. RBC, WBC, PCV, Haemoglobin content and differential count was estimated from the peripheral blood of normal, DAL control and extract treated animal groups. Haemoglobin and RBC level that generally goes down during the progression of tumor was found to improve in mice treated with MEGT. The total WBC counts which were significantly higher in the DAL control mice was found to be reduced in treated groups. This indicates that MEGT possesses protective action on the haemopoietic system. In short, the present work indicates that the MEGT exhibited significant effect on Tumor growth and haematological parameters against DAL cell lines.

Index Terms—Green tea, Anticarcinogenic, Daltons ascites lymphoma, Methanolic extract

Cite: B Geetha and K S Santhy, "Tumor Reducing and Anticarcinogenic Activity of Green Tea against Daltons Ascites Lymphoma Cells," International Journal of Pharma Medicine and Biological Sciences, Vol. 2, No. 3, pp. 92-96, July 2013.
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