Abstract—UTI is one of the most common infectious diseases in clinical settings. Though Escherichia coli is the most frequently isolated pathogen, the frequency of Staphylococcus aureus has increased over time along with the corresponding increase in the occurrence of MRSA.The knowledge of prevalent strains of MRSA and their antibiotic susceptibility pattern is important to determine the best empiric treatment option.This study was designed to determine the prevalence and anti- microbial sensitivity profile of MRSA among uropathogens. A total of 38 S. aureus isolates from 1075 urine samples were studied for the detection of methicillin resistance using 30 ¦Ìg cefoxitin disc as per CLSI guidelines. Antimicrobial sensitivity of MRSA isolates was determined against commonly recommended antibiotics. Out of 38 S. aureus isolates, 14 (36.84)were found to be methicillin resistant. Linezolide (100%) and nitrofurantoin (78.57%) were found to be most effective drugs against MRSA isolates. Amoxyclav (48%), pristinamycin (7.14%) and co-trimoxazole (7.14%) were the least effective drugs. All strains (100%) studied were resistant to doxycycline and norfloxacin. In our geographical area cotrimoxazole, doxycycline and norfloxacin should no longer be considered as the first line drugs. Nitrofurantoin and amoxiclav can be used as an alternative drug only after the sensitivity testing. Linezolide can be kept as reserve drug for the treatment of complicated UTI. We suggest strict practice of infection control measures and antimicrobial stewardship program, to contain these strains.