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Effect of A Siderophore Producer on Animal Cell Apoptosis: A Possible Role as Anti-Cancer Agent

Ismini Nakouti1, Prakitsin Sihanonth2, Tanapat Palaga2, and Glyn Hobbs1
1 School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK.
2 Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, 10300, Thailand.
Abstract—Iron plays an essential role in the proliferation of aggressive tumors therefore it represents an ideal target for cancer therapy. Cell free supernatants from a siderophore producing actinobacterium previously isolated from Thailand were tested against six human cancer cell lines including malignant melanoma A 375 (ATCC no.: CRL-1619), colorectal adenocarcinoma SW620 (ATCC no.: CCL-227), gastric carcinoma Katob III (ATCC no.: HTB-103), liver hepatoblastoma HepG2 (ATCC no.: HB-8065), breast carcinoma BT474 (ATCC no.: HTB-20) and Acute T cell leukemia Jurkat (ATCC no.: CRL-2063). Following treatment of cells with the bacterial culture supernatant the cell viability of A375 cells was dramatically decreased with cell survival of less than 34 % within 48 h. The rest of the cell lines were largely unaffected. Therefore it is suggested that the actinobacterium produced a cytotoxic compound responsible for the cell death by inducing apoptotic activity. We further speculate that this compound was desferioxamine E as the bacterium is known to produce this compound under the culture conditions used.

Index Terms—Siderophores, Actinobacteria, Human cell cancer lines, Apoptosis

Cite: Ismini Nakouti, Prakitsin Sihanonth, Tanapat Palaga, and Glyn Hobbs, "Effect of A Siderophore Producer on Animal Cell Apoptosis: A Possible Role as Anti-Cancer Agent," International Journal of Pharma Medicine and Biological Sciences, Vol. 2, No. 2, pp. 1-5, April 2013.
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