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Evaluation of Estrogenic Activity of Alcoholic Extract of Fruits of Solanum xanthocarpum using Uterine Wet Weight, Uterine Glycogen Content and Uterine Histology as Parameter of Assessment

Qumre Alam1, Vijayanarayana K1, and D Satyanarayana2
1 Department of Pharmacology, Al-Ameen College of Pharmacy, Hosur road, near lalbagh main gate, Bangalore 560027.
2 Department of Pharmacology, Nitte Gulabi Shetty Memorial Institute of Pharmaceutical Sciences, Deralakatte, Paneer, Mangalore 574160.
Abstract—The objective was to conduct a comparative study of estrogenic activity of alcoholic extract of fruits of Solanum xanthocarpum with diethylstilbestrol in bilaterally ovariectomized young albino rats using uterine wet weight, uterine glycogen content and uterine histology as parameters of assessment. Materials and Methods: Bilaterally overiectomized albino rats were divided into five groups (n=7) receiving different treatments, consisting of vehicle (distilled water), ethanolic extract of fruits of Solanum xanthocarpum at three different doses (viz., 100, 200, 400 mg/kg body weight) and standard drug diethylstilbestrol (DES) at a dose of 2 mg/kg body weight. All drugs were administered orally daily for 7 days. Estrogenic activity was assessed by taking uterine wet weight, uterine glycogen content, and uterine histology as parameters of assessment. Results: The results proved the estrogenic activity of extracts for dose 200 & 400 mg/kg body weight by exhibiting the significant ( p\<0.05 & p\<0.01) result for various parameters like uterine wet weight, uterine glycogen content and uterine histology. But the dose 100 mg/kg of Solanum xanthocarpum was proved statistically insignificant in above mentioned parameters. Conclusion: Solanum xanthocarpum showed moderate estrogenic activity in a dose dependent manner compared to diethylstilbestrol.

Index Terms—Solanum xanthocarpum , estrogenic activity, ovariectomized rats.

Cite: Qumre Alam, Vijayanarayana K, and D Satyanarayana, "Evaluation of Estrogenic Activity of Alcoholic Extract of Fruits of Solanum xanthocarpum using Uterine Wet Weight, Uterine Glycogen Content and Uterine Histology as Parameter of Assessment ," International Journal of Pharma Medicine and Biological Sciences, Vol. 1, No. 2, pp. 99-108, October 2012.
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