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Structure and Biological Activities of Novel Phytochemicals Cu(II)-Quercetin Thiosemicarbazone and Its Derivatives: Potential Anti-Cancer Drugs

Subrahmanyam Naidu P V and Prakash MMS Kinthada
Department of Chemistry, Gitam Institute of Technology, Gitam University, Visakhapatnam 530045 AP, India.
Abstract—Some promising novel phytochemicals quercetin thiosemicarbozone Copper(II)metal complex, quercetin 3-O-glucoside thiosemicarbozone Copper(II)metal complex and their rutin have been synthesized and characterized by elemental analysis by spectral FT-IR, HNMR,ESR,C13NMR, UV-Vis and Mass. The spectral and other data indicate that all the Cu(II) metal complexes are tetrahedral and octahedral(rutin) structure. The quercetin and quercetin 3-O-glucoside thiosemicarbozone ligands(QTSC) and (QOTSC), its Schiff¡¯s bases and Copper(II)-metal chelates would be screened in vitro for anticancer activity against some cancer cell lines. The transitional metal complexes of Quercetin thiosemicarbazone (QTSC) and Quercetin 3-O- glucoside thiosemicarbozone(QOTSC) ligands possess anti-oxidant, anti-tumor, anti-cancer, anti-viral, anti-malarial, anti-fungal, and anti-microbial. These activities are normally increased upon coordination, so they are suitable ligands for the synthesis of potential anti-cancer agents. In Our present research work, Quercetin derivatives most frequently occurring in the nature to determine the impact of their Chemical structure and Biological Activity. We would further synthesize the schiffs bases of certain of the constituents viz. flavanoids / phytochemicals and later synthesize their Transition metal Complexes especially eith Platinum, Gold, Palladium, Ruthenium, Cobalt, Iron, Nickel, Zinc and Chromium. The precursors, the derivatives/Analogues and the Transition metal Complexes, are all excellent candidates as Anticancer Drugs.

Index Terms—Quercetin Thiosemicarbazone,(QTSC), Quercetin 3-O-glycoside Thiosemicarbazone (QOTSC), Rutin, Cu (II)-metal complexes, Schiff's bases

Cite: Subrahmanyam Naidu P V and Prakash MMS Kinthada, " Structure and Biological Activities of Novel Phytochemicals Cu(II)-Quercetin Thiosemicarbazone and Its Derivatives: Potential Anti-Cancer Drugs," International Journal of Pharma Medicine and Biological Sciences, Vol. 1, No. 2, pp. 55-65, October 2012.
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